Submit Manuscript  

Article Details


An Overview on Bacteriophages: A Natural Nanostructured Antibacterial Agent

[ Vol. 15 , Issue. 1 ]

Author(s):

Vaibhav Rastogi*, Pragya, Navneet Verma, Arun Kumar Mishra, Gopal Nath, Praveen Kumar Gaur and Anurag Verma   Pages 3 - 20 ( 18 )

Abstract:


Background: Recent advances in the field of bionanomedicine not only enable us to produce biomaterials but also to manipulate them at molecular level. Viruses particularly bacteriophages are a promising nanomaterial that can be functionalized with great precision. Bacteriophages are the natural antimicrobial agents that fight against antibiotic resistant bacteria which cause infections in animals, humans, or in crops of agricultural value. The idea of utilizing bacteriophages as therapeutic agents is due to their ability to kill bacteria at the end of the infectious cycle.

Objective: This paper reviewed the general biology of bacteriophages and the presence of receptors on the bacteria which are necessary for the recognition and adsorption of bacteriophages. Pharmacokinetics and therapeutic potential of bacteriophages administered through various routes in treating diverse bacterial infections is also reviewed along with the problems associated with bacteriophage therapy.

Conclusion: Among various routes of administration, parenteral route is found to be the most thriving route for the treatment of systemic infections whereas oral route is meant to treat gastrointestinal infections and; local delivery (skin, nasal, ears) of phages has proven its potency to treat topical infections.

Keywords:

Bacterial receptors, bacteriophage, bionanomedicine, delivery routes, pharmacokinetics, antibacterial agents.

Affiliation:

Department of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, 244001, Department of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, 244001, Department of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, 244001, Department of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, 244001, Department of Microbiology, Institute of Medical Science, Banaras Hindu University, Varanasi, Uttar Pradesh, 221005, Department of Pharmaceutics, I.T.S. Paramedical College (Pharmacy), Muradnagar, Ghaziabad, Uttar Pradesh, 201206, Department of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, 244001

Graphical Abstract:



Read Full-Text article