Maha Nasr, Sameh Abdel-Hamid, Noha H. Moftah, Maha Fadel and Abdullah A. Alyoussef Pages 426 - 432 ( 7 )
Background: Nanotechnology has provided substantial benefits in drug delivery, especially in the treatment of dermatological diseases. Psoriasis is a chronic inflammatory skin disease in which topical delivery of antipsoriatic agents is considered the first line treatment.
Objective: To investigate whether the encapsulation of the synthetic retinoid tazarotene in a nanocarrier based on jojoba oil would decrease its irritation potential and clinically improve its therapeutic outcome in psoriatic patients.
Method: A microemulsion system based on jojoba wax and labrasol/plurol isostearique was prepared and characterized.
Results: The selected formula displayed spherical morphology, particle size of 15.49±2.41 nm, polydispersity index of 0.20 ±0.08, negative charge and low viscosity. The microemulsion provided two folds increase in skin deposition of tazarotene, correlating with higher reduction in psoriatic patients PASI scores after treatment (68% reduction in PASI scores versus 8.96% reduction with the marketed gel). No irritation was encountered in patients using microemulsion, with redness and inflammation reported with the marketed gel-treated patients.
Conclusion: Jojoba oil microemulsion proved to be advantageous in reducing the irritancy of tazarotene, enhancing its skin deposition and achieving better therapeutic outcome in psoriatic patients.
Ex-vivo deposition, jojoba oil, microemulsion, pseudoternary phase diagram, psoriasis, tazarotene.
Ain Shams University, Faculty of Pharmacy, Department of Pharmaceutics and Industrial Pharmacy- Monazamet El Wehda El Afrikia St., El Abbassia, Cairo,, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo,, Department of Dermatology, STDs and Andrology, Faculty of Medicine, Al-Minya University, Al-Minya,, Pharmaceutical Technology Unit, Department of Medical Applications of Lasers, National Institute of Laser Enhanced Sciences, Cairo University, Cairo,, Dermatology Department, Tabuk University