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Photothermal Ablation of Cancer Cells Using Folate-Coated Gold/ Graphene Oxide Composite

[ Vol. 14 , Issue. 3 ]

Author(s):

Nicolò Mauro, Anna Li Volsi, Cinzia Scialabba, Mariano Licciardi, Gennara Cavallaro and Gaetano Giammona   Pages 433 - 443 ( 11 )

Abstract:


Objective: A new tumor targeted polymer-coated gold/graphene hybrid has been developed for achieving simultaneously thermoablation and chemoterapy of folate receptor-positive cancer cells.

Methods: The gold/graphene hybrid was prepared by depositing gold nanospheres onto graphene oxide and coating it with an inulin-folate conjugate. Paclitaxel was loaded by sonication. The hybrid was characterized by UV-Vis spectroscopy, DSC analysis and SEM microscopy. The cytotoxicity, thermoablation and anticancer activity were evaluated in vitro on MCF-7 and 16 HBE.

Results: In vitro tests showed that the paclitaxel-loaded hybrid improved the effectiveness of the drug especially after photothermal treatments.

Conclusion: On the whole, while gold/graphene composite provided an excellent time-dependent photothermal effect, the loading of paclitaxel allowed a suitable chemotherapy, thus killing cancer cells both via a selective laser beam thermoablation and hyperthermia-triggered chemotherapy.

Keywords:

Gold nanoparticles, graphene, hyperthermia, inulin, folate, paclitaxel, thermal ablation.

Affiliation:

Laboratory of Biocompatible Polymers, Department of Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Via Archirafi, 32 90123 Palermo,, Laboratory of Biocompatible Polymers, Department of Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Via Archirafi, 32 90123 Palermo,, Laboratory of Biocompatible Polymers, Department of Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Via Archirafi, 32 90123 Palermo,, Laboratory of Biocompatible Polymers, Department of Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Via Archirafi, 32 90123 Palermo,, Laboratory of Biocompatible Polymers, Department of Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Via Archirafi, 32 90123 Palermo,, Laboratory of Biocompatible PolymeLaboratory of Biocompatible Polymers, Department of Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Via Archirafi, 32 90123 Palermo,rs, Department of Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Via Archirafi, 32 90123 Palermo, Italy

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