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The Sustained Effects on Tear Volume of Pilocarpine Hydrochloride in Gelatin by Hydrogel Administered by An Implant-mediated Drug Delivery System

[ Vol. 14 , Issue. 4 ]

Author(s):

Seunghee Cha, Hong-Kyun Kim, Hong-Seop Kho and Young-Seok Park*   Pages 581 - 586 ( 6 )

Abstract:


Background: Pilocarpine hydrochloride is commonly prescribed to patients with dry mouth and eye using a frequent dosing schedule. The aim of this study was to evaluate the sustained effects of this highly soluble drug carried by a gelatin hydrogel, which was administered by an implant mediated drug delivery system (IMDDS).

Methods: The IMDDS was installed in a total of 24 rabbits. After complete healing, pilocarpine hydrochloride was administered as 30 mg as raw powder (Group 1; n = 8), 30 mg in gelatin hydrogel (Group 2; n = 8), and 60 mg in gelatin hydrogel (Group 3; n = 8). The effects were evaluated by tear volume measured using the Schirmer tear test for 2 weeks after administration.

Results: All 3 groups showed an increase in tear volume from the initial measurement at 1 hour. Group 1 exhibited this increase for 24 hours, while Groups 2 and 3 sustained this increase for 5 days and 7.5 days, respectively.

Conclusion: When provided in gelatin hydrogel, highly water-soluble pilocarpine hydrochloride administered through IMDDS resulted in sustained effects with increased tear volume in normal rabbits.

Keywords:

Dry eye, hydrogel, implant-mediated drug delivery system, osseogate, pilocarpine hydrochloride, sustained release.

Affiliation:

Oral and Maxillofacial Diagnostic Sciences, College of Dentistry, University of Florida, Gainesville, Department of Oral Anatomy, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Department of Oral Medicine and Oral Diagnosis, School of Dentistry, Seoul National University, Seoul, Department of Oral Anatomy, Seoul National University School of Dentistry, P.O. Box: 03080, Seoul

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