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Porphyrin-containing Gadolinium Complex as a Tumor-targeting Magnetic Resonance Imaging (MRI) Contrast Agent

[ Vol. 15 , Issue. 7 ]

Author(s):

Yao-Hua Ouyang, Wei Xu, Cheng-Kai Zhou, Fan Liu, Bin Li, Guo-Ping Yan*, Lian Yang, Si Chen and Can Jiang   Pages 972 - 978 ( 7 )

Abstract:


Objective: Gadolinium diethylenetriaminepentaacetic di[5-(4’-amidophenyl)-10,15,20- tris(4’-sulfonatophenyl) porphyrin trisodium salt] (Gd-DTPA-2APTSPP) was synthesized by the reaction of diethylenetriaminepentaacetic dianhydride with 5-(4’-aminophenyl)-10,15,20-tris(4’-sulfonatophenyl) porphyrin and subsequently chelation with gadolium chloride.

Methods: This gadolinium complex was characterized and its properties in vitro and in vivo were also evaluated. Compared with Gd-DTPA, Gd-DTPA-2APTSPP possessed high relaxivity r1, low cytotoxicity to HeLa cells and high enhanced signal intensities of the VX2 carcinoma in rabbits for a prolonged time.

Conclusion: Moreover, Gd-DTPA-2APTSPP can distinguish the VX2 carcinoma from the reactive hyperplasia incited by inflammation and normal tissues in rabbits. Therefore, Gd-DTPA-2APTSPP can be taken up selectively by tumors and show the potential as a tumor-targeting MRI contrast agent.

Keywords:

Magnetic resonance imaging (MRI), contrast agent, gadolinium complex, porphyrin, VX2 carcinoma, tumortargeting.

Affiliation:

School of Materials Science and Engineering, Wuhan Institute of Technology, 693 Xiongchu Road, Wuhan 430074, Hubei Province, School of Materials Science and Engineering, Wuhan Institute of Technology, 693 Xiongchu Road, Wuhan 430074, Hubei Province, Center for Magnetic Resonance Imaging of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, School of Materials Science and Engineering, Wuhan Institute of Technology, 693 Xiongchu Road, Wuhan 430074, Hubei Province, School of Materials Science and Engineering, Wuhan Institute of Technology, 693 Xiongchu Road, Wuhan 430074, Hubei Province, School of Materials Science and Engineering, Wuhan Institute of Technology, 693 Xiongchu Road, Wuhan 430074, Hubei Province, Center for Magnetic Resonance Imaging of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, School of Materials Science and Engineering, Wuhan Institute of Technology, 693 Xiongchu Road, Wuhan 430074, Hubei Province, School of Materials Science and Engineering, Wuhan Institute of Technology, 693 Xiongchu Road, Wuhan 430074, Hubei Province

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