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Permeation Efficacy of a Transdermal Vehicle with Steroidal Hormones and Nonsteroidal Anti-inflammatory Agents as Model Drugs

[ Vol. 16 , Issue. 2 ]

Author(s):

Laura A. Junqueira*, Hudson Polonini, Sharlene Loures, Nádia R.B. Raposo, Anderson O. Ferreira and Marcos Antônio F. Brandão   Pages 136 - 141 ( 6 )

Abstract:


Background: Transdermal delivery is an alternative route for the administration of drugs. However, it requires the development of vehicles that allow the drugs to cross the layers of the skin and reach the systemic circulation.

Objective: In this study, a new transdermal vehicle was evaluated using progesterone, estradiol, estradiol + estriol (Biest) and ketoprofen administered as model drugs.

Methods: To evaluate the ex vivo permeation of the drugs, the Franz vertical diffusion cell with human skin was used.

Results: After 24 h, the vehicle was able to deliver 18.32 µg/cm2 of progesterone and 92.07

Keywords:

Transdermal vehicle, ex vivo permeation, progesterone, estriol, estradiol, ketoprofen.

Affiliation:

NUPICS- Núcleo de Pesquisa e Inovação em Ciências da Saúde, Universidade Federal de Juiz de Fora, Juiz de Fora, Ortofarma Laboratory, Matias Barbosa, Ortofarma Laboratory, Matias Barbosa, NUPICS- Núcleo de Pesquisa e Inovação em Ciências da Saúde, Universidade Federal de Juiz de Fora, Juiz de Fora, NUPICS- Núcleo de Pesquisa e Inovação em Ciências da Saúde, Universidade Federal de Juiz de Fora, Juiz de Fora, Ortofarma Laboratory, Matias Barbosa



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