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Release Kinetics of Nicotine Loaded onto Mesoporous Silicate Materials for Use in Nicotine Replacement Therapy

[ Vol. 16 , Issue. 10 ]

Author(s):

Fadia Ijbara, Dua’a M. Marzouqa, Murad A. Al Damin and Hamdallah A. Hodali*   Pages 951 - 958 ( 8 )

Abstract:


Objective: In this work, the loading of nicotine onto mesoporous silicate materials and its release into a phosphate buffer solution at 37°C were investigated.

Methods: The mesoporous silicate materials designated as MCM-41 were prepared with different pore sizes via using alkyltrimethylammonium bromide surfactants with different alkyl chain lengths of carbon atoms 12, 14, and 16. The mesoporous silicate systems were characterized by X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), N2-adsorption–desorption isotherms, and FT-IR spectroscopy.

Results: Loading of nicotine was confirmed by FTIR and thermal gravimetric analysis and was determined by High-Performance Liquid Chromatography (HPLC).

Conclusion: A slight increase in loading capacity with increasing pore size was observed, with a loading capacity of about 17% for MCM-41(16). The release of nicotine was monitored by HPLC and was almost complete for MCM-41(14) and MCM-41(16) in 8 h.

Keywords:

Nicotine, MCM-41, mesoporous materials, drug delivery, HPLC, FTIR, NRT.

Affiliation:

Department of Chemistry, The University of Jordan, Amman 11942, Department of Chemistry, The University of Jordan, Amman 11942, Department of Chemistry, The University of Jordan, Amman 11942, Department of Chemistry, The University of Jordan, Amman 11942



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