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In-Vitro and In-Vivo Evaluation of Supersaturable Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Dutasteride

[ Vol. 17 , Issue. 1 ]

Author(s):

Poonguzhali Subramanian, P. S. Rajnikanth*, Manish Kumar and Kumarappan Chidambram   Pages 74 - 86 ( 13 )

Abstract:


Objective: A novel, Supersaturable Self-Nanoemulsifying Drug Delivery System (S-SNEDDS) has been prepared to improve the Dutasteride's poor aqueous solubility.

Methods: By adding Hydroxy Propyl Methyl Cellulose (HPMC) as a precipitation inhibitor to conventional SNEDDS, a supersaturable system was prepared. Firstly, the prepared SNEDDS played an important role in increasing the aqueous solubility and hence oral absorption due to nano-range size. Secondly, the S-SNEDDS found to be advantageous over SNEDDS for having a higher drug load and inhibition of dilution precipitation of Dutasteride. Formulated S-SNEDDS (F1-F9) ranged from 37.42 ± 1.02 to 68.92 ± 0.09 nm with PDI 0.219-0.34 and drug loading of over 95 percent.

Results: The study of in-vitro dissolution revealed higher dissolution for S-SNEDDS compared to SNEDDS and Avodart soft gelatin capsule as a commercial product. In addition, higher absorption was observed for S-SNEDDS showing approximately 1.28 and 1.27 fold AUC (0-24h) and Cmax compared to commercial products. Therefore, S-SNEDDS has proven as a novel drug delivery system with a higher drug load, higher self-emulsification efficiency, higher stability, higher dissolution and pronounced absorption.

Conclusion: In conclusion, S-SNEDDS could be a newly emerging approach to enhance aqueous solubility in many folds for drugs belonging to BCS Class II and IV and thus absorption and oral bioavailability.

Keywords:

Supersaturated Self-Nanoemulsifying Drug Delivery (S-SNEDDS), Hydroxy Propyl Methyl Cellulose (HPMC), Dutasteride, higher self-emulsification efficiency, Poor Aqueous Solubility, Nano-emulsion.

Affiliation:

School of Pharmacy, Taylor’s University Lake view Campus, Subang Jaya, Selangor, School of Pharmacy, Taylor’s University Lake view Campus, Subang Jaya, Selangor, Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, Uttar Pradesh, School of Pharmacy, Taylor’s University Lake view Campus, Subang Jaya, Selangor

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