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Gelatin and Glycerine-Based Bioadhesive Vaginal Hydrogel

[ Vol. 17 , Issue. 4 ]

Author(s):

Roberta Cassano, Federica Curcio, Delia Mandracchia, Adriana Trapani and Sonia Trombino*   Pages 303 - 311 ( 9 )

Abstract:


Aim: The work’s aim was the preparation and characterization of a hydrogel based on gelatin and glycerine, useful for site-specific release of benzydamine, an anti-inflammatory drug, able to attenuate the inflammatory process typical of the vaginal infection.

Objective: The obtained hydrogel has been characterized by Electronic Scanning Microscopy (SEM) and Differential Scanning Calorimetry (DSC). In addition, due to the precursor properties, the hydrogel exhibits a relevant mucoadhesive activity.

Methods: The swelling degree was evaluated at two different pHs and at defined time intervals. In particular, phosphate buffers were used at pH 6.6, in order to mimic the typical conditions of infectious diseases at the vaginal level, particularly for HIV-seropositive pregnant women, and pH 4.6, to simulate the physiological environment.

Results: The obtained results revealed that the hydrogel swells up well at both pHs.

Conclusion: Release studies conducted at both pathological and physiological pHs have shown that benzydamine is released at the level of the vaginal mucosa in a slow and gradual manner. These data support the hypothesis of the hydrogel use for the site-specific release of benzydamine in the vaginal mucosa.

Keywords:

Gelatin, glycerine, hydrogel, mucoadhesive, vaginal, pH.

Affiliation:

Department of Pharmacy, Health and Nutritional Sciences, Università della Calabria, Arcavacata di Rende, Cosenza, Department of Pharmacy, Health and Nutritional Sciences, Università della Calabria, Arcavacata di Rende, Cosenza, Department of Pharmacy, Universita degli Studi di Bari Aldo, Bari, Department of Pharmacy, Universita degli Studi di Bari Aldo, Bari, Department of Pharmacy, Health and Nutritional Sciences, Università della Calabria, Arcavacata di Rende, Cosenza

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