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Recent advances in self-assembled nanoparticles for drug delivery

Author(s):

Lanke Tejesh Verma, Nidhi Singh, Bapi Gorain, Hira Choudhury, Murtaza M. Tambuwala, Prashant Kesharwani* and Rahul Shukla  

Abstract:


Collection of different bulk materials forms the nanoparticles, where the properties of the nanoparticle are solely differing from the individual components before ensemble. Self-assembled nanoparticles are basically a group of complex functional unit that are formed by assembly of the individual bulk components of the system. It includes micelles, polymeric nanoparticle, carbon nanotubes, liposomes and niosomes etc. This self-assembly has been progressively heightened interest to control the final complex structure of the nanoparticle and its associated properties. The main challenge of formulating self-assembled nanoparticle is to improve the delivery system, bioavailability, enhance circulation time, confer molecular targeting, controlled release, protection of the incorporated drug from external environment and also serves as nanocarriers for macromolecules. Ultimately, these self-assembled nanoparticles facilitate to overcome the physiological barriers in vivo. Self-assembly is equilibrium process where both individual and assembled components are subsisting in equilibrium. It is bottom up approach in which molecules are assembled spontaneously, non-covalently into stable and well-defined structure. There are different approaches has been adopted in fabrication of self-assembled nanoparticles by the researchers. The current review is enriched with strategies for nanoparticle self-assembly, associated properties, and its application in therapy.

Keywords:

Anti-inflammatory, antioxidant, chalcones, hypochlorous acid, myeloperoxidase inhibition, neutrophils, aminochalcones, reactive oxygen species, redox potential, scavenger capacity, Self-assembly, driving forces, nanoparticle, mesoporous silica nanoparticle, gold nanoparticle, liposome

Affiliation:

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER, Raebareli), Raebareli (U.P), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER, Raebareli), Raebareli (U.P), School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, Subang Jaya, Selangor, 47500, Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, SAAD Centre for Pharmacy and Diabetes, School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine, County Londonderry, BT52 1SA, Northern Ireland, School of Pharmaceutical Education and Research, Jamia Hamdard (Hamdard University), New Delhi, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER, Raebareli), Raebareli (U.P)



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