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Encapsulating Rifampicin into SLNs: A Viable Option for Managing its Bioavailability Issues Upon Co-Delivery with Isoniazid

[ Vol. 17 , Issue. 4 ]

Author(s):

Harinder Singh, Ruchi Sood, Tridib Chaira, Alka Khanna, Dilip J Upadhaya, Ramesh Bambal, Pradip K. Bhatnagar, Mandeep Singh and Indu Pal Kaur*   Pages 343 - 347 ( 5 )

Abstract:


Background: Rifampicin is known to degrade at the acidic pH of the stomach, especially in the presence of isoniazid. Although isoniazid also degrades partially, its degradation is reversible.

Objective: Presently, we provide a proof of the fact that the simultaneous oral administration of rifampicin (RIF), upon incorporation into solid lipid nanoparticles (RIF-SLNs), with isoniazid (INH) overcomes its INH-induced degradation and improves its oral bioavailability in rats.

Methods: Solid lipid nanoparticles of RIF (RIF-SLNs) were prepared using a novel and patented method. The effect of INH was investigated on in vivo bioavailability of RIF both in its free and encapsulated (RIF-SLNs) form, after oral administration to rats.

Results: Cmax and AUC0-∞ of RIF increased 158 % and 125 %, respectively, upon incorporation into SLNs versus free RIF when combined with INH. The Tmax decreased from 5.67 h to 3.3 h, and the plasma concentration of RIF remained above its MIC (8 μg/ml) at all the tested time points starting with 15 min, when administered as RIF-SLNs in combination with INH.

Conclusion: The results confirm the scope of combining RIF-SLNs with INH to overcome the bioavailability of free RIF when combined with INH, especially in fixed dose combinations.

Keywords:

Oral bioavailability, drug interaction, oral administration, fixed dose combinations, Solid lipid nanoparticles, Isoniazid

Affiliation:

University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, Daiichi Sankyo Life Science Research Centre in India, A unit of Daiichi Sankyo India Pharma Pvt Limited, Village Sarhaul, Sector-18, UdyogVihar Industrial Area, Gurgaon-122015, Haryana, Daiichi Sankyo Life Science Research Centre in India, A unit of Daiichi Sankyo India Pharma Pvt Limited, Village Sarhaul, Sector-18, UdyogVihar Industrial Area, Gurgaon-122015, Haryana, Daiichi Sankyo Life Science Research Centre in India, A unit of Daiichi Sankyo India Pharma Pvt Limited, Village Sarhaul, Sector-18, UdyogVihar Industrial Area, Gurgaon-122015, Haryana, Daiichi Sankyo Life Science Research Centre in India, A unit of Daiichi Sankyo India Pharma Pvt Limited, Village Sarhaul, Sector-18, UdyogVihar Industrial Area, Gurgaon-122015, Haryana, Daiichi Sankyo Life Science Research Centre in India, A unit of Daiichi Sankyo India Pharma Pvt Limited, Village Sarhaul, Sector-18, UdyogVihar Industrial Area, Gurgaon-122015, Haryana, Daiichi Sankyo Life Science Research Centre in India, A unit of Daiichi Sankyo India Pharma Pvt Limited, Village Sarhaul, Sector-18, UdyogVihar Industrial Area, Gurgaon-122015, Haryana, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014

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