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Nanovesicular photodynamic clinical treatment of resistant plantar warts

Author(s):

Maha Fadel, Kawser Kassab, Nevien Samy, Doaa Abdelfadeel, Ghada Yassin and Maha Nasr Sayed*  

Abstract:


Background: Photodynamic therapy which involves the use of photosensitizer molecule activated by a light source was proven very promising for treatment of dermatological diseases, especially the resistant ones such as recalcitrant plantar warts (PW).

Objective: However, its efficacy is hindered by the poor permeation of the photosensitizer molecule required to initiate skin photo-induced effects.

Methods: In this manuscript, the efficiency of nano-vesicular system (transfersomes) as potential topical drug delivery system for the photosensitizer methylene blue (MB) was investigated following clinical photodynamic therapy (PDT) in patients suffering from PW.

Results: Results revealed that MB transfersomal gel displayed higher complete healing percentage for the lesions compared to the free MB gel (86.67% versus 53.57%) achieved at lower number of treatment sessions (2.2 versus 4.14). Patients reported no signs of pain or inflammation, with no recurrence of the lesions during the follow up period of 8 months.

Conclusion: PDT using transfersomal MB as an effective and safe therapeutic modality for the treatment of PW.

Keywords:

Topical delivery, Methylene blue, clinical, plantar warts, transfersomes, photodynamic therapy

Affiliation:

Department of Medical Laser Applications, Pharmaceutical Nanotechnology Unit, National Institute of Laser Enhanced Sciences, Cairo University , Department of Medical Laser Applications, Cairo University, Dermatology Department, Cairo University, Department of Medical Laser Applications, Cairo University , Department of Medical Laser Applications, Cairo University, Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Ain Shams University



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