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Nanostructured Lipid Carriers (NLCs) for Drug Delivery: Role of Liquid Lipid (Oil)

Author(s):

Anisha D’Souza and Ranjita Shegokar*   Pages 1 - 22 ( 22 )

Abstract:


In recent years, SLNs and NLCs are among the popular drug delivery systems studied for delivery of lipophilic drugs. Both systems have demonstrated several beneficial properties as an ideal drug-carrier, optimal drug-loading and good long-term stability. NLCs are getting popular due to their stability advantages and possibility to load various oil components either as an active or as a matrix. This review screens types of oils used till date in combination with solid lipid to form NLCs. These oils are broadly classified in two categories: Natural oils and Essential oils. NLCs offer range advantages in drug delivery due to the formation of imperfect matrix owing to the presence of oil. The type and percentage of oil used determines optimal drug loading and stability. Literature shows that variety of oils is used in NLCs mainly as matrix, which is from natural origin, triglycerides class. On the other hand, essential oils not only serve as a matrix but as an active. In short, oil is the key ingredient in formation of NLCs, hence needs to be selected wisely as per the performance criteria expected.

Keywords:

Lipid nanoparticles, Solid Lipid Nanoparticles (SLNs), Nanostructured Lipid Carriers (NLCs), solid lipid, liquid lipid, fixed oils, encapsulation of oils, essential oils, homogenization.

Affiliation:

Indian Institute of Technology-Bombay (IIT-B), Department of Bioscience and Biomedical Engineering, Powai, Mumbai, FreieUniversität Berlin, Institute of Pharmacy, Department Pharmaceutics, Biopharmaceutics, And Nutricosmetics, Berlin



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