Ozgur Esim, Ayhan Savaser, Leyla Karadurmus, Nurgul K. Bakirhan, Sibel A. Ozkan and Yalcin Ozkan* Pages 1 - 26 ( 26 )
Migraine is a chronic, painful, neurological disorder that affects approximately 15% of the population worldwide. It is a form of neurovascular headache: a disorder in which neural events result in the dilation of blood vessels that, in turn, results in pain and further nerve activation. The pathogenesis of migraine was not completely understood but it is thought that both central and peripheral stimulations can play a role in migraine. Experimental pharmacological evidence suggests that some drugs can have actions at migraine treatment and oral drug delivery is the first choice for these drugs. However, the oral absorption of many drugs is delayed during migraine attacks. Therefore, there may be an advantage to other drug delivery routes such as parenteral and intranasal. Moreover, nanoparticles can be used for improved drug delivery of anti-migraine agents as they can protect the encapsulated drug from biological and/or chemical degradation, and extracellular transport by P-gp efflux proteins. Various analytical studies have been performed to sensitive and selective assays of antimigraine drugs from commercial and real samples. The single or combination with other drugs of anti-migraines can be easily detected by several analytical methods such as ultraviolet spectrometry, visible spectrometry, high performance liquid chromatography, liquid chromatography- mass spectrometry, high performance thin layer chromatography. This review focuses on the status of anti-migraine drug delivery technologies and possible routes for drug delivery. Moreover, it will present their analytical assays with different methods.
Antimigraine Drugs, Drug Delivery System, HPLC, UV Spectrophotometry, Electrochemical Analysis, CNS Drug Delivery
University of Health Sciences, Gulhane Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, University of Health Sciences, Gulhane Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, Department of Analytical Chemistry, Faculty of Pharmacy, Adıyaman University, Adıyaman, University of Health Sciences, Gulhane Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, University of Ankara, Faculty of Pharmacy, Department of Analytical Chemistry, 06100, Ankara, University of Health Sciences, Gulhane Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara