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Recent Advances in Treatment of Lung Cancer: Nanoparticle-based Drug and siRNA Delivery Systems

Author(s):

Ayse Gencer, Ceren Duraloglu, Sena Ozbay, Turkmen T. Ciftci, Samiye Yabanoglu-Ciftci and Betul Arica*   Pages 1 - 17 ( 17 )

Abstract:


Lung cancer is the second most diagnosed cancer in both men and women worldwide. Considering the high mor-tality rate of lung cancer indicating the inadequacy of conventional treatment methods such as surgical resection, chemo-therapy and radiotherapy; new treatment strategies is an emerging area of interest. Nanoparticle-based drug and siRNA de-livery systems such as lipid, polymeric and inorganic nanoparticles, micelles and dendrimers are designed to enhance the bioavailability, stability and retention of the anti-cancer drug in the targeted regions of lung. These nanoparticle-based de-livery systems provide increased active ingredient half-life, targeting efficiency and reduced the required dose of the drug. Hence, they havemany advantages such as higher therapeutic efficacy, lower side effects, reducing adverse events. Combi-nations of active ingredients, anti-cancer agents and siRNA, can be formulated in nanoparticle-based delivery system that can be administered by variousroutes including inhalation and intravenous. In this review, development of lipidic and pol-ymeric nanoparticle-based drug and siRNA delivery systems used in the treatment of lung cancer are discussed.

Keywords:

Lung cancer, drug delivery, gene delivery, nanotechnology, siRNA, lipid and polymer-based nanocarriers.

Affiliation:

Department of PharmaceuticalTechnology, Faculty of Pharmacy, Hacettepe University, Ankara, Department of PharmaceuticalTechnology, Faculty of Pharmacy, Hacettepe University, Ankara, Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Department of Radiology, Faculty of Medicine, Hacettepe University, Ankara, Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Department of PharmaceuticalTechnology, Faculty of Pharmacy, Hacettepe University, Ankara



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