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Glyceryl Monostearate Based Solid Lipid Nanoparticles for Controlled Delivery of Docetaxel

Author(s):

Nadia Rai, Asadullah Madni*, Amir Faisal, Talha Jamshaid, Muhammad Imran Khan, Muhammad Muzamil Khan and Farzana Parveen  

Abstract:


Background: Solid Lipid Nanoparticles (SLNs) is the drug delivery systems that has the capability to improve drug release at the desired tumor site. The aim of present study was to develop Glyceryl Monostearate (GMS) based SLNs for the controlled delivery of docetaxel.

Method: Hot Melt Encapsulation (HME) method was employed avoiding the use of organic solvents and therefore, regarded as green synthesis of SLNs.

Results: Optimized DTX-SLNs showed desirable size (100 nm) with low poly dispersity index and excellent entrapment efficiency. Surface charge confirmed the stability of formulation. Transmission Electron Microscope (TEM) analysis showed spherical shaped particles and Fourier Transform Infrared Microscopy (FTIR) revealed compatibility among formulation excipients. Differential Scanning Calorimeter (DSC) analysis revealed that melting transition peak of optimized formulation was also greater than 40°C indicating that SLNs would be solid at body temperature. In-vitro release profile (68% in 24 hours) revealed the controlled release profile of DTX-SLNs indicating lipophilic docetaxel drug was entrapped inside high melting point lipid core. Cytotoxicity study revealed that blank SLNs were found to be biocompatible while dose dependent cytotoxicity was shown by DTX-SLNs.

Conclusion: These studies suggest that DTX-SLNs have potential for controlled delivery of docetaxel and improved therapeutic outcome.

Keywords:

SLNs, GMS, docetaxel, hot melt encapsulation, breast cancer, controlled drug delivery, ovarian cancer.

Affiliation:

Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur 63100, Bahawalpur, Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur 63100, Bahawalpur, Department of Biology, Lahore University of Management Sciences, Lahore, Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur 63100, Bahawalpur, Faculty of Pharmaceutical Sciences, Riphah International University Lahore, Lahore, Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur 63100, Bahawalpur, Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur 63100, Bahawalpur



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