Sonia Parashar, Manish Kumar Sharma, Chanchal Garg and Munish Garg*
Unprincipled use of antibiotics has led to the antimicrobial resistance (AMR) against mostly available compounds and now become a major cause of concern for the scientific community. However, in the past decade, green synthesized silver nanoparticles (AgNPs) have received greater attention for the development of newer therapies as antimicrobials by virtue of their unique physico-chemical properties. Unlike traditional antibiotics, AgNPs exert their action by acting on multiple mechanisms which make them potential candidates against AMR. Green synthesis of AgNPs using various medicinal plants has demonstrated broader spectrum of action against several microbes in a number of attempts. The present paper provides an insight into the scientific studies that have elucidated the positive role of plant extracts/phytochemicals during green synthesis of AgNPs and their future perspectives. The studies conducted so far seem promising still, a few factors like, the precise mechanism of action of AgNPs, their synergistic interaction with biomolecules, and industrial scalability need to be explored further till effective drug development using green synthesized AgNPs in healthcare systems against AMR is established.
Antimicrobial resistance; Silver nanoparticles; Synergism; Green synthesis; Antibiotics; Microbes.
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, Haryana, Department of Chemistry, Deenbandhu Chhotu Ram University of Science and Technology, Murthal (Sonipat) 131039, Haryana, Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, Haryana, Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, Haryana