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Cyclodextrin Based Nanosponges: A Multidimensional Drug Delivery System and its Biomedical Applications

Author(s):

Preeti Tanaji Mane*, Balaji Sopanrao Wakure and Pravin Shridhar Wakte   Pages 1 - 27 ( 27 )

Abstract:


Cyclodextrin based nanosponges are the designed nanocarriers for the projected delivery of complex drugs. They are multifunctional hypercrosslinked cyclodextrin polymers connected in a three-dimensional, mesh-like network. Their functional characteristics can be fabricated by using different crosslinkers or their different rations with polymer. They can encapsulate various hydrophilic, lipophilic, small-sized or large-sized drug molecules. They offer formulation flexibility and are primarily used for solubility, bioavailability and stability enhancement purposes. This system is also pliable for co-delivery of pharmaceutical entities, improving therapeutic efficacy and patient compliance. If the surface of nanosponge is coupled with an appropriate ligand, even a target specific drug delivery can be achieved. It has a variety of applications in the field of pharmacy for the delivery of tricky drug molecules, proteins, enzymes, natural moieties and gaseous compounds. The list of its applications further widens with the development of nanodiagnostics, nanosensors, biomimetics and scaffolds based on nanosponges. The sudden explosion of research in this working area signifies cyclodextrin nanosponge based products in the market soon.

Keywords:

Nanosponges, cyclodextrin based nanosponges, drug delivery, solubility, bioavailability, encapsulation.

Affiliation:

University Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, University Campus, near Soneri Mahal, Jaisingpura Aurangabad, Maharashtra 431004, Vilasrao Deshmukh Foundation School of Pharmacy, Vilasrao Deshmukh Foundation group of institutions, New MIDC, Airport Road, Latur, Maharashtra 413531, University Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, University Campus, near Soneri Mahal, Jaisingpura Aurangabad, Maharashtra 431004



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