Vandana Singh Suryavanshi*, Tungabidya Maharana and Pratik Kumar Jagtap
Introduction: The plant used in the present study is Cassia fistula, which belongs to the family Leguminosae and has been used in Traditional medicinal systems ever since due to presence of copious amount of Phytochemicals with varying properties.
Aims: This study is focussed on the extraction of phytochemicals from Cassia fistula flower and its subsequent encapsulation into chitosan matrix for applications in drug delivery. Chitosan is approved by FDA for its use in Pharmaceutical industries.
Methods: The microsphere thus prepared by the current study is predicted to release the desired extract with medicinal properties in a controlled manner allowing more convenient and desired levels of drug administration as been characterized by several analytical techniques like FT-IR, NMR, Thermal analysis, SEM. The swelling study and release study of the prepared microsphere has been carried out in physiological pH 2 and 7.4. NMR study has shown that sitosterol and friedelin have been encapsulated successfully into the chitosan matrix.
Results: The microspheres has shown upto 80% swelling in pH 2 upto 8 days and 60% of the in-vitro controlled drug release has also been found in pH 2 upto 2 days. The thermal studies using TGA and DSC supported the thermal stabilities of CS beads, CFFE and CFFE-CS beads also it showed the dispersion of the CFFE in the cavities of Chitosan matrix. Conclusion: The Biomedical application of the synthesized CFFE-CS beads have also been reported on the basis of their antibacterial studies.
Cassia fistula; Chitosan; Encapsulation; Microspheres; Drug release; Antibacterial study
Department of Chemistry, Govt. D.B.D. College, Baloda Bazar, Chhattisgarh, Department of Chemistry, National Institute of Technology, Raipur, Chhattisgarh, Department of Chemistry, Kalinga University, Naya Raipur, Chhattisgarh