J. Jordan, F.J. Fernandez-Gomez, M. Ramos, I. Ikuta, N. Aguirre and M.F. Galindo Pages 225 - 231 ( 7 )
In this review we explore and integrate the knowledge of the plausible pharmacological targets that could explain the new application for the well known semi-synthetic, tetracycline-derivate minocycline as a cytoprotective drug. In doing so, we will analyze the possible mechanisms to elucidate the potential cytoprotective properties of minocycline. We address its anti-oxidant action ranging from its structure to its capacity to modulate the expression of oxidant-related enzymes such as nitric oxide synthase. The pharmacological targets responsible for its anti-inflammatory effects are surveyed. The effects of this antibiotic are making its marks on intracellular pathways related to neurodegenerative processes such as mitochondrially-mediated apoptosis, including minocycline-modulated effects on the expression of apoptotic proteins. Finally, we will explore the effects of minocycline on metalloproteinases, enzymes implicated in the modulation of cerebrovascular post-ischemic oxidative reperfusion injury, and new targets. In conclusion, we shed new light on the shadowy controversy of minocyclines potential cytoprotective mechanisms and targets of action.
Anti-inflammatory, anti-oxidant, apoptosis, cytoprotection, minocycline, mitochondria, modulation of the expression of anti-apoptotic proteins, reactive oxygen species
Grupo de Neurofarmacologia,Departamento de Ciencias Medicas, Facultad de Medicina, Universidad de Castilla-La Mancha, Avda. Almansa, 14, 02006 Albacete, Spain.