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Chronotherapeutic Approach to Design A Thermoresponsive Membrane for Transdermal Drug Delivery

[ Vol. 1 , Issue. 3 ]


Shan-Yang Lin   Pages 249 - 263 ( 15 )


In this review, the concepts of chronobiology, circadian rhythm, chronopharmacology, homeostasis and chronotherapy are taken into account to approach the optimal drug therapy, in which the timing of drug administration plays an important role. Based on these considerations, our laboratory has developed a thermo-responsive membrane by entrapping a single or binary liquid crystal to achieve an on-off switching drug delivery for transdermal application via the externally repeated cycle of temperature change, which may simulate the dosing time of therapeutic needs for human body.


on-off thermo-responsive, cellulose membrane, coc, cn, liquid crystal, circadian rhythm, chronotherapy, transdermal


Biopharmaceutical Laboratory, Department of Medical Research&Education, Taipei VeteransGeneral Hospital, Taipei, Taiwan, Republic of China

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