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Peptide-Based Subunit Nanovaccines

[ Vol. 8 , Issue. 3 ]

Author(s):

Mariusz Skwarczynski and Istvan Toth   Pages 282 - 289 ( 8 )

Abstract:


Classical vaccines incorporating live or attenuated microorganisms possess several disadvantages and cannot be applied against cancer and some pathogens. Modern vaccines utilizing immunogenic subunits derived from a particular pathogen are able to overcome these obstacles but need a specific delivery system for their efficacy. Nanotechnology has opened a new window into these delivery methodologies. A nano-sized formulation of subunit vaccines has been proven to be very effective in inducing cellular and humoral immune responses. Here, we review a number of peptide vaccine delivery strategies based on nanoparticles composed of polymers, peptides, lipids, and inorganic materials.

Keywords:

Subunit vaccine, peptide epitope, nanotechnology, nanoparticles, infectious diseases, Nanovaccine, autoimmunity, lipid carriers, inorganic materials, pathogens

Affiliation:

The University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia, Qld 4072, Australia.



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