Divya Thakur, Gurpreet Kaur*, Ashana Puri and Rajat Nanda
A pre-eminent emulsion based micellar drug delivery system, “microemulsion”, comprising of drug in oil or water phase, stabilized by surfactants and co-surfactants, has been evidenced to have phenomenal role in number of applications. Oils play an important role in formation of ME and increase the drug absorption at the site of action. Oils employed in microemulsion formulation solubilize lipophilic drug. As concept of “natural” therapies is recently gaining importance amongst researchers all over the world, scientists are employing essential oil as an organic component in this system. The active components of essential oils include flavonoids, phenylpropanoids, monoterpenes and polyunsaturated of mega-6-fatty acids. These oils are enriched with characteristic intrinsic properties such as anti-oxidant, anti-bacterial, anti-viral, etc. bestows an enhanced supremacy to whole microemulsion system. This mini-review is the first to document various types of essential oils employed in microemulsion systems and highlight their therapeutic potential and applications as drug delivery vehicles. Key inferences from this study suggest: 1) Clove oil is the most explored oil for incorporation into microemulsion based system, followed by peppermint and Tea Tree Oil (TTO). 2) Penetration enhancing effects of these oils is due to the presence of terpenic constituents. 3) Essential oil based microemulsions protect volatility of ethereal oils and protect them from degradation in presence of light, air, temperature. 4) These systems may also be explored for their applications in different industries like aromatherapy, food, drink, fragrance, flavour, cosmeceutical, soap, petroleum and pharmaceutical industry.
Anti-microbial, clove oil, essential oil, microemulsions, tea tree oil, fatty acids.
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala (Punjab) , Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala (Punjab) , Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City 37614, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala (Punjab)