Raja Murugesan and Sureshkumar Raman*
At present, treatment methods for cancer are limited, partially due to the solubility, poor cellular distribution of drug molecules and, the incapability of drugs to affect the cellular barriers. Carbon nanotubes (CNTs) generally have excellent physio-chemical properties, which include high-level penetration into the cell membrane, high surface area and high capacity of drug-loading by circulating modification with bio-molecules, projecting them as an appropriate candidate to diagnose and deliver drugs to prostate cancer (PCa). Additionally, the chemically modified CNTs, which have excellent 'Biosensing' properties, therefore, make it easy to detect PCa without a fluorescent agent and thus target the particular site of PCa. In this way, drug delivery can accomplish a high efficacy, enhanced permeability with less toxic effects. While CNTs have been mainly engaged in cancer treatment, a few studies are focused on the diagnosis and treatment of PCa. Here, we reviewed the current progress of the CNTs based diagnosis and targeted drug delivery system for managing and curing PCa.
Prostate cancer, biosensor, carbon nanotubes, diagnosis, drug delivery system, bioimaging.
Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty