Tahereh Zadeh Mehrizi*, Seyed Mahdi Rezayat, Mehdi Shafiee Ardestani, Hasan Ebrahimi Shahmabadi and Amitis Ramezani
In the present review study, the published articles from 2010-2020 that evaluated the effect of chitosan nanocarrier on the amphotericin B (AmB) efficacy in the treatment of leishmaniasis, have been considered. Leishmania is a parasitic tropical disease in the world and is treated with AmB as one of the main therapeutic agent. However, clinical application of AmB is limited due to its toxicity and insolubility issues. Using nanoparticles and in particular chitosan nanocarrier seems a promising approach to overcome these problems. Therefore, various doses of AmB have been loaded in chitosan nanoparticles in different studies and the results of these studies demonstrated that by increasing the drug loading efficiency and decreasing the toxicity, the potency of the nanoformulation to inhibit and killing the parasite is increased. In this regard, the results of a study performed in 2018, demonstrated that chitosan nanoparticles with the higher dose of drug loading were the most effective formulation to inhibit and kill the parasite. Thus, chitosan nanocarrier can consider as an appropriate candidate in the future to inhibit and kill the leishmania parasite without causing side effects.
Amphotericin B, in vivo, leishmaniasis, nanochitosan, toxicity, treatment
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Department of Microbiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Department of Clinical Research, Pasteur Institute of Iran, Tehran